tesi

Yonghong Liang Ph.D. Talaaga o le olaga aoga faigaluega

Yonghong Liang Ph.D. Talaaga o le olaga aoga faigaluega

Maualuga ausia

Atinaʻega Suesuega

  • Sep. 2006-nei Galulue i Ph.D (Organic Chemistry)
    galuega faatino
    1. O se suʻesuʻega faʻapitoa o le fegalegaleaiga i le va o lepivirine (TMC120) ma le HIV-1 faʻaliliuina le transcriptase
    2. Aotelega o mafutaga vavalalata sootaga o le benrylary diarylpyrimidines
    3. Design, synthesis ma suʻesuʻega a le SAR o le α poo le β naphthyl substituted diarylpyrimidines e pei o ni inhibitors non-nucleoside o le HIV-1 reverse transcriptase
    4. Fuafuaga ma faʻasalalauga o DABO e avea ma toʻalua inhibitors o le HIV-1 liliu mai transcriptase ma faʻatasi

  • 2003-2006 Pule Sili
    galuega faatino
    1. O le eleele- ma le fiafia-tulaga o le intrammolecular proton transfer mo 2-hydroxybenzophenone, 8-hydroxy-4H-naphthalen-1-one, 5-hydroxy-4, 5-naphthoquinone, 1-hydroxy-9, 10-anthraquione, 7-Hydroxy -1-indenone, 5, 8-dihydroxy-1, 4-naphthoquinone), 4, 9-dihydroxyperylene-3, 10-quinone ma hypocrellin na suesueina A e metotia tau o ni faaupuga.
    2. Le eleele-tulaga faaliliuina proton inermolecular i le complexes o 5-hydroxyisoxazole-vai, DNA (RNA) faavae dimer ma faavae-N-methylformamide na faia e auala DFT.
    2002-2003 Faʻatusatusaga o le faʻatulagaina o meatotino-meatotino i luga o le fale o le physicochemical o le ketone ma aldehyde

faailoga Taualoa

Hunan Province Excellence Master Study, 2008

lomiga

1. Liang, YH; Chen, FE ONIOM DFT / PM3 faʻatusatusa i le fegalegaleaiga i le va o le vaapifirine ma le HIV-1 reverse transcriptase, o se suʻesuʻega masani. Drug Discov. Ther. 2007, 1, 57-60.

2. Liang, YH; Chen, FE QSAR suʻesuʻega mo diarylpyrimidines e faasaga i le HIV-1 faʻaaogaina o le transcriptase ituaiga o manu feʻai ma manua. Eur. J. Med. Chem. 2009, 44, 625-631

3. Liang, YH; Feng, XQ; Zeng, ZS; Chen, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Design, tuufaatasia, ma SAR o Naphthyl-suia Diarylpyrimidines o lē Nucleoside Inhibitors o HIV-1 faafeagai Transcriptase. ChemMedChem 2009, 4, 1537-1545.

4. Feng, XQ; Liang, YH; Zeng, ZS; Chen, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Faʻatulagaina o Faʻatulagaga o Analogues DAPY ma le Gafatia o le HIV-1. ChemMedChem 2009, 4, 219.

5. Zeng, ZS; Liang, YH; Feng, XQ; Chen, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. optimization Sulu o diarylpyrimidines pei inhibitors o lē nucleoside HIV-1 transcriptase faafeagai, ChemMedChem 2010, taliaina.

6. Liang, YH; Yi, PG Suʻesuʻega faʻapitoa i luga o le fausaga, malosi ma le intrammolecular proton transfer o alkannin. Vailaau Faʻasologa o Vailaau Mataʻitusi, 2007, 438, 173.

7. Liang, YH; Yi, PG; Peng, HL suesuega faʻalemafaufau, o fausaga, faaliliuina hydrogen malolosi ma intramolecular o hypocrellin A. oona fisiki Lettters, 2008, 466, 6-10.

8. Liang, YH; Yi, PG. Cao, CZ O se suʻesuʻega faʻapitoa i luga o le fesoso-proided transfer proton i 5-hydroxyisoxazole. Lautusi o le Molecular Structure: Theochem, 2005, 729, 163-167.

9. Yi, PG .; Liang, YH; Cao, CZ O le faʻasolosolo faʻamalosi poʻo le faʻaaogaina o le hydrogen-atom i le eleele ma le fiafia o setete o 2-hydroxybenzophenone: O se suʻesuʻega faʻapitoa. Vailaʻau Mataʻutia, 2005, 319, 297.

10. Yi, PG .; Liang, YH O suʻesuʻega faʻapitoa o le faʻasalaga ma aʻafiaga laiti i luga o le fesuiaiga o le proton i totonu o le eleele ma le fiafia i setete. Vailaʻau Mataʻutia, 2006, 322, 382.

11. Yi, PG .; Liang, YH Tang, ZQ Suʻesuʻega faʻapitoa o le faʻaaogaina o le protoncular proton transferentia i totonu o complexes 5-hydroxyisoxazole-vai. Vailaʻau Faʻataʻi, 2006, 2006, 322, 387.

12. Liang, YH; Zeng, ZS; Feng, XQ; Chen, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Faʻailoga Faʻatasi ma le Iloiloga Ola o Diarylpyrimidines faʻatasi ai ma gaioiga ole HIV-1. Med. Chem. 2010, 18 (13), 4601.

13. Liang, YH; Zeng, ZS; Feng, XQ; Chen, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Faʻatulagaina o DABO e pei o ni inhibitors e lua o le HIV-1 liliu mai transcriptase ma faʻatasi. J. Med. Chem.

14. Chen, FE, Liang, YH Alualu i Luma o le Alualu i luma o Vailaʻau Faʻataʻi-Tomaʻi Faʻataʻi, Taʻi i le Faʻataʻitaʻi Faʻataʻitaʻi (8), Peng, SQ Ed., 2011, 167.

15. Chen, FE, Liang, YH, Zeng, ZS PCT / CN2009 / 075931.

16. Zeng, ZS, Liang, YH, Zhang, JY, Xiong, JC China Patent, CN201110070027.4

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